Натрия (гидроксиметил) глицинат

Description

Sodium (hydroxymethyl) glycinate is the sodium salt of N-(hydroxymethyl) glycine, C3H7NO3·Na. Cosmetic preservative of the formaldehyde donor class: as part of the formulation, the compound slowly splits off formaldehyde, which provides antimicrobial protection. Trade designations from the card are Sattotsid A, Integra 44, Nuosept 44. According to INCI nomenclature - Sodium Hydroxymethylglycinate.

Identification

• CAS No: 70161-44-3
• Chemical formula: C3H7NO3 Na
• English name: Sodium (hydroxymethyl)glycinate
• EU number: 274-357-8
• UNII: DIG6BWZ9XT
• DSSTox ID: DTXSID5035799
• HS code: 2922509090
• Synonyms: glycine N-(hydroxymethyl) sodium salt, Sattotsid A, Integra 44, Nuosept 44
• Catalog section: amphoteric surfactants

Basic Attributes

• Molecular weight: 127.07
• Exact weight: 127.024536
• Polar surface PSA: 72.39
• XLogP3: −2.3334
• Appearance: Liquid
• Boiling point: 307.2 °C at 760 mm Hg. Art.
• Flash point: 139.6 °C

XLogP3 −2.3334 - pronounced hydrophilicity: the preservative is distributed in the aqueous phase of the emulsion, where the growth of microorganisms occurs. The commercial form is an aqueous solution, which also includes the physical state indicated on the card.

Mechanism of action

The hydroxymethyl group at the nitrogen atom represents bound formaldehyde. In the formulation, the equilibrium gradually shifts towards its elimination; free formaldehyde denatures proteins and nucleic acids of the microbial cell. The concentration of released formaldehyde remains low, but is maintained continuously - hence the prolonged effect compared to a single injection of the biocide. The release increases with heating and with a shift in pH.

Scope of application

• preservative for cosmetic and perfume formulations: suppression of the growth of bacteria and fungi in the aqueous phase
• hair care products - shampoos, conditioners
• creams, lotions, soaps, children's cosmetics
• household chemicals and technical water compositions

Regulatory status

In the European Union, the substance is permitted as a preservative with a maximum concentration of 0.5%. In this case, the use is prohibited if the maximum concentration of released formaldehyde in the mixture placed on the market is 0.1% by weight or more. The limitation directly follows from the mechanism of action and requires calculation of the total release of formaldehyde for all donors in the formulation.

Stability

Incompatible with strong oxidizing agents.

Safety

• Hazard Statements: H302 - Harmful if swallowed; H315 - Causes skin irritation
• GHS classification: “Warning”, H302 (49.24% of notifications) with measures P261, P264, P270, P272, P280, P301+P312, P302+P352, P305+P351+P338, P321, P330, P333+P313, P337+P313, P363, P501; separate entry H302 (100%); H315 with measures P261, P264, P272, P280, P302+P352, P305+P351+P338, P321, P332+P313, P333+P313, P337+P313, P362, P363, P501
• Tags: Xn
• Hazard class code: 22-36
• Safety instructions: 26

Aggregated GHS information was provided by 307 companies from 10 notifications and 20 companies from 1 notification to the ECHA C&L Register. The substance can cause sensitization and irritation of the skin and eyes - when added to the formulation, the concentration is kept within the limits of the regulations; work with the concentrate is carried out with gloves and goggles.

Storage

The container is tightly closed, away from strong oxidizing agents. Overheating the concentrate accelerates the release of formaldehyde and reduces the content of the active substance.