Оксихлоросин

Description

Oxychlorosine is an antiseptic, which is a complex of hypochlorous acid with alkylbenzenesulfonic acid. According to the PubChem structural notation, it is a combination of HOCl and 4-tetradecylbenzenesulfonic acid. The sodium salt of the substance, sodium oxychlorosine, is available as a powder for the preparation of a solution under the brand name Clorpactin WCS-90. The product is not used in dry form, but in the form of a freshly prepared aqueous solution.

Basic Attributes

• CAS No: 8031-14-9
• Chemical formula on the card: C14H29X, C6H5O3SX, ClHO
• Molecular Weight: 407.006
• Exact weight: 406.194
• UNII: 3214M86B2N
• DSSTox ID: DTXSID40230248
• PSA: 83

Writing the formula on the card reflects the composition of a complex of three fragments - a tetradecyl chain, a benzenesulfonate group and hypochlorous acid, and not a single covalent molecule.

Mechanism of action

The activity of the substance is determined by the release of hypochlorous acid in a buffer medium. Released HOCl chlorinates and oxidizes the cell membranes of microorganisms and destroys the contents of the cytoplasm. At the same time, the alkylbenzenesulfonate part of the complex works: as a surfactant, it reduces surface tension and facilitates the penetration of the oxidizer into the biofilm and wound detritus. The combination of oxidative and detergent action gives a wide bactericidal spectrum against almost all microorganisms.

Applications

• washing infected wounds and cavities - by irrigation, soaking or spraying
• instillation into the bladder: historically for bladder tuberculosis in the 1940s, later for interstitial cystitis
• antiseptic treatment of mucosal surfaces for local treatment of infections

The procedure for preparing the solution according to the instructions for Clorpactin WCS-90: pour the contents of one bottle into a quart of cool or lukewarm water in a glass or plastic container; the resulting solution is used immediately.

Composition of the product form

Clorpactin WCS-90 contains sodium dodecylbenzenesulfonate; active chlorine is obtained from calcium hypochlorite, the content of available chlorine is 3–4%, total chlorine is 6–8%.

Storage and handling

The dry powder is kept in a tightly closed container, in a cool, dry place, separate from reducing agents and organic materials: as a source of active chlorine, the substance is an oxidizing agent. Metal utensils are not used when preparing the solution - only glass or plastic. Solutions are not stored: active chlorine is quickly lost, so the drug is prepared immediately before the procedure.